CLINICAL EVIDENCE & RESEARCH

Clinical Evidence & Research

Specific, verifiable evidence — an independent clinical study, peer-reviewed publications, and physician-authored education. Every entry links to its primary source.

Evidence: Strong · Independent Clinical Study

Clinically shown to visibly lighten age spots in 8 weeks through independent image analysis.

In an independent 8-week study of 35 women (ages 48–70, mean 62.8), VISIA-CR 5 image analysis showed age-spot mean intensity improved +7.07% vs baseline, with 79.41% of participants improving (p < 0.0001). Higher VISIA intensity means lighter pigmentation, so the increase represents visible lightening of age spots. No adverse events across the study. Conducted by International Research Service, Inc. (IRSI Inc.), an ALS Global company; Principal Investigator Barry T. Reece, M.S., M.B.A.

At Week 8, participants also reported (all statistically significant): 82.9% smoother skin, 82.9% firmer skin, 82.9% more radiant, 80.0% would buy, 80.0% would recommend, 88.6% safe for daily use.

View the clinical record (zenodo.org)

Evidence: Peer-Reviewed · Publications

Selected peer-reviewed publications

1. From Metabolomics to Function: Ranking Plant Stem Cell Metabolomes for Use in Health and Cosmetics. Zemach A, … Newman N. Biomolecules. 2026;16(5):695.

2. Yeast-Plant-Derived Consortia Factors Exhibit a Distinct and Enriched Beneficial Metabolome for Health and Beauty. Zemach A, … Newman N. bioRxiv, 2026.

3. Novel, Reproducible, Consortia Factors Derived from Adipose Stem Cells for Burn Wound Treatment. Talavera-Adame D, … Newman N. Stem Cells and Cloning. 2025;18:63-72. (PMID 40495998).

4. Conventional and Novel Stem Cell-Based Therapies for Androgenic Alopecia. Talavera-Adame D, Newman D, Newman N. Stem Cells and Cloning. 2017;10:11-19.

Full 13-publication list plus three Springer textbook chapters available on request.